Peripheral artery disease (PAD) affects nearly 8 million adults in the United States. Intermittent claudication, leg pain with exertion, is a cardinal symptom of peripheral artery disease (PAD) and occurs in as many as 30-50% of individuals with PAD. Claudication results, in part, from decreased perfusion to the exercising skeletal muscle due to arterial stenosis.
We are doing this research study to find out if abnormal creation of energy stores in the leg muscles may contribute to leg muscle pain in patients with PAD. In PAD, the arteries (blood vessels) in the legs are narrowed because of the build up of plaque. The leg muscle can hurt in patients with PAD and this is usually described as a cramp or tiredness. This pain is called intermittent claudication. We also want to find out if exercise improves walking distance by making the leg muscles create more energy.
You may be eligible to participate in this research study if you:
- ≥ 40 years old
- Have pain in your leg muscles when walking due to blocked blood flow
- Or have previously been diagnosed with peripheral artery disease (PAD)
- Do NOT have diabetes
If you or someone you know may be interested in participating, click here.
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